Be aware: Certain prescription drugs reduce the psychoactive effects of magic mushrooms. SSRIs (like Prozac, Paxil, Zoloft, Celexa, Desyrel) or MAOIs (like Nardil, Parnate, Marplan, Eldepryl, Aurorix, Manerix) can diminish what are magic mushrooms like the effects and render them more unpredictable. Do not mix prescription drugs with psilocybin. In addition to the index of known and suspected psychoactive mushrooms, Psilocybin Mushrooms of the World also contains Stamets' reflections on the cultural, and even spiritual, significance of magic mushrooms. He also provides some context about their use by ancient peoples (particularly in Mexico), and their "rediscovery" in 1957 with the publication of "Seeking the Magic Mushroom" in Life magazine. Its focus is on treatment-resistant depression, or TRD, a subset of depressive disorder, or MDD, comprising patients who are inadequately served by the treatment paradigm. It has developed a proprietary, high-purity polymorphic crystalline formulation of psilocybin, COMP360.